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Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
Published on: February 3, 2017
Adipose tissue-derived cells improve cardiac function following myocardial infarction
Katja Schenke-Layland1, Brian M Strem, Maria C Jordan
1Cardiovascular Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at the University of California-Los Angeles (UCLA), Los Angeles, California 90095-1760, USA.
The Journal of Surgical Research
|August 13, 2008
Summary
Freshly isolated adipose tissue-derived cells (ADCs) significantly improved heart function after myocardial infarction in rats. ADCs promote new blood vessel growth, offering a novel therapeutic approach for cardiac repair.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Stem Cell Biology
Background:
- Adipose tissue contains adipose tissue-derived cells (ADCs), including mesenchymal stem cell-like populations.
- Adipose tissue-derived stem cells are clinically advantageous due to their immediate availability in sufficient quantities for therapeutic use without ex vivo expansion.
Purpose of the Study:
- To evaluate the therapeutic potential of freshly isolated ADCs in a rat model of acute myocardial infarction (MI).
Main Methods:
- Rats experienced induced myocardial infarction followed by reperfusion.
- Fifteen minutes post-MI, rats received an injection of either saline or 5 x 10^6 ADCs into the left ventricle.
- Left ventricular function and structure were monitored for 12 weeks using echocardiography, followed by histological analysis.
Main Results:
- ADC treatment led to significantly improved ejection fraction and cardiac output, with less ventricular dilation compared to controls after 12 weeks.
- Despite functional improvements, absolute cell engraftment rates were low.
- ADC treatment increased both capillary and arteriole densities in the heart.
Conclusions:
- Freshly isolated ADCs demonstrate therapeutic benefits when administered post-MI.
- ADCs may exert their beneficial effects through a potent proangiogenic mechanism, promoting new blood vessel formation.