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Possible association between long anterior lens zonules and plateau iris configuration
Daniel K Roberts1, Radha Ayyagari, Sayoko E Moroi
1*Illinois Eye Institute, Illinois College of Optometry, Chicago, IL 60616, USA. droberts@eyecare.ico.edu
Journal of Glaucoma
|August 16, 2008
Summary
Long anterior zonule (LAZ) is associated with plateau iris configuration (PIC). This finding suggests LAZ may indicate a higher risk for angle closure glaucoma.
Area of Science:
- Ophthalmology
- Genetics
Background:
- The long anterior zonule (LAZ) is a clinical trait that may predispose individuals to angle closure.
- Plateau iris configuration (PIC) is another ocular finding associated with increased risk of angle closure.
Observation:
- This study investigated the presence of PIC in subjects with the LAZ trait.
- High-resolution ultrasonography was used to image three elderly LAZ subjects, two with persistent angle closure and one with narrow angles.
Findings:
- All three LAZ subjects exhibited plateau iris configuration (PIC).
- The association between LAZ and PIC was statistically unlikely to be due to chance.
- No subjects carried the S163R mutation in the C1q tumor necrosis factor-related protein 5 gene (C1QTNF5/CTRP5).
Implications:
- The findings suggest a potential association between LAZ and PIC, warranting further investigation.
- LAZ may serve as a clinical indicator for increased risk of PIC and angle closure glaucoma.
- Genetic factors beyond the S163R CTRP5 mutation may be involved in the LAZ phenotype.
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