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Updated: Jul 2, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Published on: November 12, 2015

Generalized posterior keratoconus: clinical pathologic correlations.

Devesh K Varma¹, Seymour Brownstein, William G Hodge

¹University of Ottawa, Ottawa Hospital Eye Institute, Ottawa, Ontario, Canada.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie

|August 20, 2008

Summary

This summary is machine-generated.

This study reports the first histopathological findings of generalized posterior keratoconus, revealing an absence of Bowman's layer and amyloid deposits consistent with polymorphous amyloid degeneration.

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Area of Science:

Ophthalmology
Histopathology
Corneal Diseases

Background:

Generalized posterior keratoconus is a rare corneal condition.
Understanding its histopathological features is crucial for diagnosis and management.

Observation:

A 73-year-old woman presented with bilateral generalized posterior keratoconus.
Corneal thickness measurements showed thinning centrally and thickening peripherally.
Histopathological examination of the corneal specimen revealed the absence of Bowman's layer.

Findings:

Focal homogeneous oval stromal deposits were identified.
These deposits stained positive for amyloid.
The findings were consistent with polymorphous amyloid degeneration.

Implications:

This case provides the first histopathological evidence of generalized posterior keratoconus.
The absence of Bowman's layer and presence of amyloid deposits are key diagnostic markers.
Further research may elucidate the pathogenesis of this rare condition.