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Updated: Jul 2, 2026
09:31
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
[Livid polycyclic plaques of the lower extremities]
V Bekou1, I Franke, H Gollnick
1Klinik für Dermatologie und Venerologie, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Deutschland.
Summary
Leukemia cutis (LC), a skin manifestation of acute myelomonocytic leukemia, presents with varied lesions and indicates a poor prognosis. Early dermatological diagnosis is crucial for timely treatment of the underlying leukemia.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Leukemia cutis (LC) is a significant skin manifestation in 10%-55% of acute myelomonocytic leukemia (AMML) cases.
- LC presence is strongly associated with a poor overall prognosis in AMML patients.
Observation:
- Clinical presentation of LC can include disseminated bluish-violet or red-brownish papules, plaques, nodules, and hemorrhagic ulcers.
- Distinguishing between specific malignant cell infiltrates and nonspecific leukemid infiltrates is critical in patients with dermatoses and hematologic neoplasms.
Findings:
- The varied dermatological presentations of LC can mimic other skin conditions.
- Accurate differentiation between specific and nonspecific skin infiltrates is essential for correct diagnosis.
Implications:
- Dermatologists play a vital role in the rapid clinical and dermatohistopathological diagnosis of LC.
- Prompt diagnosis facilitates immediate and appropriate treatment of the underlying systemic leukemia, improving patient outcomes.
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