Related Experiment Video
Updated: Jul 2, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
Normal pressure hydrocephalus: diagnosis and treatment
David Shprecher1, Jason Schwalb, Roger Kurlan
1University of Rochester School of Medicine, 1351 Mt. Hope Avenue, Suite 100, Rochester, NY 14620, USA. David_Shprecher@urmc.rochester.edu
Abstract:
Normal pressure hydrocephalus (NPH) is a syndrome of gait dysfunction and enlarged cerebral ventricles in the absence of another cause. It is frequently accompanied by frontal and subcortical cognitive deficits and bladder detrusor overactivity. NPH is rare relative to other potential causes of these symptoms in the elderly, but timely diagnosis can lead to reversal of symptoms through ventricular shunting. There are many tests used to predict possible response to surgery, such as MRI of the brain, formalized neuropsychological and gait testing, large-volume lumbar puncture, and prolonged lumbar drainage, but no one test has been validated to rule out potential response to surgery.
Related Concept Videos
Increased Intracranial Pressure l: Introduction
Increased Intracranial Pressure ll: Pathophysiology
Brain Abscess l: Introduction
Cerebral Edema ll: Pathophysiology
Cerebral Edema l: Introduction
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
