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[Precocious pubertal].

Jean-Claude Carel1, Delphine Zenaty, Anne Paulsen

  • 1Service d'endocrinologie-diabétologie pédiatrique, centre de référence des maladies endocriniennes rares de la croissance, hôpital Robert-Debré, Université Paris-Diderot Paris-7, 75935 Paris Cedex 19, France. jean-claude.carel@inserm.fr

La Revue Du Praticien
|August 22, 2008
PubMed
Summary
This summary is machine-generated.

Precocious puberty requires careful evaluation to identify hypothalamic lesions in central cases. Not all precocious puberty cases progress, and GnRH agonists are considered for confirmed central precocious puberty.

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Area of Science:

  • Pediatric endocrinology
  • Neuroendocrinology
  • Reproductive medicine

Context:

  • Precocious puberty is a common endocrine disorder in children.
  • Accurate assessment of pubertal timing is crucial.
  • Identifying the underlying cause, such as hypothalamic lesions, is essential for central precocious puberty.

Purpose:

  • To outline the evaluation and management of precocious puberty.
  • To discuss the diagnostic criteria for central precocious puberty.
  • To present treatment options, including Gonadotropin-releasing hormone (GnRH) agonists, and their long-term outcomes.

Summary:

  • Precocious puberty necessitates a thorough evaluation, focusing on pubertal timing and potential hypothalamic lesions in central precocious puberty.
  • Many cases of precocious puberty do not require intervention as they may not progress.
  • Gonadotropin-releasing hormone (GnRH) agonists are a key therapeutic consideration for confirmed central precocious puberty.

Impact:

  • Provides a framework for the diagnostic workup of precocious puberty.
  • Guides clinical decision-making regarding treatment initiation and cessation.
  • Informs understanding of the long-term management and outcomes associated with precocious puberty treatments.