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Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

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Solid form screening--a review.

Jaakko Aaltonen¹, Morten Allesø, Sabiruddin Mirza

¹School of Pharmacy, University of Otago, Dunedin, New Zealand. jaakko.aaltonen@otago.ac.nz

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|August 22, 2008

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Solid form screening is crucial for drug development, impacting product lifecycle. Careful selection of active pharmaceutical ingredient (API) solid forms considers efficacy, processing, and intellectual property.

Area of Science:

Pharmaceutical Sciences
Materials Science
Drug Development

Background:

Solid form screening is integral to pharmaceutical development.
Decisions made during screening affect the entire product lifecycle.
Selection criteria balance pharmaceutical properties with intellectual property.

Purpose of the Study:

To review the fundamental principles of solid form screening.
To discuss experimental and computational methodologies.
To compare screening strategies for branded and generic drugs.

Main Methods:

Review of experimental techniques for solid form generation, characterization, and analysis.
Inclusion of data mining tools and high-throughput screening.
Overview of computational methods in solid form screening.

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Main Results:

Solid form screening involves generating and analyzing diverse solid forms of an API.
Key selection factors include therapeutic efficacy, processing, and IP.
Strategies differ between branded and generic manufacturers.

Conclusions:

Effective solid form screening requires careful design, execution, and evaluation.
The choice of solid form has long-term implications for pharmaceutical products.
Understanding diverse screening approaches is vital for successful drug development.