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Updated: Jul 2, 2026

Optimizing Tubulin Yield from Porcine Brain Tissue
Published on: October 11, 2024
Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core
Olga N Zefirova1, Evgeniya V Nurieva, Heiko Lemcke
1Department of Chemistry, M. V. Lomonosov Moscow State University, 119992 Moscow, Russian Federation. olgaz@org.chem.msu.ru
Abstract:
Several adamantane-based taxol mimetics were synthesized and found to be cytotoxic at micromolar concentrations and to cause tubulin aggregation. The extent of the aggregation is maximal for N-benzoyl-(2R,3S)-phenylisoseryloxyadamantane (5) and is very sensitive to the structural modifications. A hybrid compound (15), combining adamantane-based taxol mimetic with colchicine was synthesized and found to possess both microtubule depolymerizing and microtubule bundling activities in A549 human lung carcinoma cells.
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