Related Experiment Video
Updated: Jul 2, 2026
Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
Published on: September 16, 2025
Visual outcomes after wavefront-guided laser in situ keratomileusis with and without iris registration
Theeratep Tantayakom1, Janice N Lim, Tracy L Purcell
1Shiley Eye Center, University of California-San Diego, 9415 Campus Point Drive, La Jolla, CA 92093, USA.
Purpose:
To compare the clinical outcomes of wavefront-guided laser in situ keratomileusis in eyes in which iris registration was used (IR group) and eyes in which iris registration would not engage (no-IR group).
Setting:
Shiley Eye Center, University of California San Diego, La Jolla, California, USA.
Methods:
This retrospective analysis comprised 112 eyes of 64 patients who had wavefront-guided LASIK using the Visx CustomVue S4 IR platform (Advanced Medical Optics) for myopia or myopic astigmatism. The safety, efficacy, predictability, and need for enhancement at the 3-month follow-up were evaluated and compared between the IR group and the no-IR group.
Results:
By 3 months postoperatively, all eyes in the IR group and 93% of eyes in the no-IR group had the same best spectacle-corrected visual acuity (BSCVA) as preoperatively or had gained 1 to 2 lines of BSCVA. No eye in either group lost more than 1 line of BSCVA (P = 0.12). Ninety-six percent of eyes in the IR group and 93% in the no-IR group were within +/-0.50 diopter (D) of the postoperative manifest refraction spherical equivalent (P = 0.24), and all eyes were within +/-1.00 D of emmetropia. Four eyes in the IR group and 11 in the no-IR group required retreatment during the follow-up period (P = 0.1).
Conclusion:
The results in the IR group and the no-IR group were comparable, with no statistically significant differences in measured outcomes.
