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Published on: July 31, 2016
Pelvic perfusion for advanced colorectal cancers
Giovanni Begossi1, James F Belliveau, Harold J Wanebo
1Roger Williams Medical Center, Boston University School of Medicine, 825 Chalkstone Avenue, Providence, RI 02908, USA.
Surgical Oncology Clinics of North America
|August 30, 2008
Summary
Isolated pelvic perfusion (IPP) offers a promising approach for advanced rectal cancer when conventional treatments fail. Further research into optimizing chemotherapy and perfusion parameters could enhance its effectiveness for colorectal cancer patients.
Area of Science:
- Oncology
- Surgical Oncology
- Vascular Interventional Radiology
Background:
- Isolated pelvic perfusion (IPP) is an intra-arterial treatment for tumors in pelvic organs.
- A simplified balloon occlusion technique for IPP shows potential in palliating advanced rectal cancer.
- This approach is considered for patients unresponsive to standard chemoradiation.
Observation:
- This review examines technique criteria and patient responses from seven studies on IPP for colorectal cancer.
- The focus is on IPP's role in managing advanced or unresectable rectal cancer.
- Data synthesis from literature studies informs the evaluation of IPP's efficacy.
Findings:
- IPP demonstrates promise in improving resectability and palliation for advanced rectal cancer.
- The reviewed studies highlight the need for standardized technique criteria.
- Varied anti-tumor responses suggest a need for protocol optimization.
Implications:
- Optimizing chemotherapeutic agents and perfusion parameters is crucial for enhancing anti-tumor responses.
- Future efforts should aim to standardize the IPP procedure for improved outcomes.
- IPP may become a more refined and effective treatment option for select colorectal cancer patients.
