Related Experiment Video
Updated: Jul 2, 2026

In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
Variants in the nestin gene and coronary heart disease
Weihua Meng1, Chris C Patterson, Christine Belton
1Department of Medicine, Institute of Clinical Science, Queen's University Belfast, Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
Background:
The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported.
Methods And Results:
The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02).
Conclusion:
Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.
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