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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Published on: June 17, 2025

Papillary conjunctivitis associated with Kikuchi disease.

Anat Galor¹, Matthew Georgy, Henry A Leder

¹Division of Ocular Immunology, Johns Hopkins University, Baltimore, MD 21287, USA.

|August 30, 2008

Summary

This summary is machine-generated.

Papillary conjunctivitis can be an ocular manifestation of Kikuchi-Fujimoto disease (KFD). This case report details a patient whose conjunctivitis resolved with topical steroids, highlighting a potential association.

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Area of Science:

Ophthalmology
Rheumatology
Pathology

Background:

Kikuchi-Fujimoto disease (KFD) is a rare, benign, systemic histiocytic disorder.
KFD typically presents with fever, cervical lymphadenopathy, and constitutional symptoms.
Ocular manifestations of KFD are uncommon, making this case noteworthy.

Observation:

A 35-year-old male presented with bilateral eye redness preceding systemic symptoms of KFD.
Mediastinoscopy confirmed the diagnosis of Kikuchi-Fujimoto disease.
The patient developed bilateral papillary conjunctivitis.

Findings:

Systemic KFD was diagnosed following the onset of fever and lymphadenopathy.
Initial treatment with oral prednisone temporarily resolved ocular redness.
Topical prednisolone acetate successfully treated the papillary conjunctivitis.

Implications:

Papillary conjunctivitis should be considered in the differential diagnosis of ocular symptoms in patients with KFD.
This case expands the spectrum of known ocular presentations associated with Kikuchi-Fujimoto disease.
Further research may elucidate the immunopathogenesis linking KFD and conjunctivitis.