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Related Experiment Videos

Angle closure glaucoma precipitated by aerosolized atropine.

G J Berdy1, S S Berdy, L S Odin

  • 1Department of Ophthalmology, Harvard Medical School, Boston, Mass.

Archives of Internal Medicine
|August 1, 1991
PubMed
Summary

Inhaled atropine can trigger angle closure glaucoma by obstructing aqueous humor outflow. Patients with shallow anterior chambers should undergo ophthalmologist examination before anticholinergic inhalant therapy.

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Area of Science:

  • Ophthalmology
  • Pulmonology

Background:

  • Angle closure glaucoma (ACG) is an infrequent condition caused by peripheral iris obstruction of the trabecular meshwork, impeding aqueous humor outflow.
  • Anatomic predispositions for ACG include small anterior segments, thickened lenses, and shallow anterior chamber depth.

Observation:

  • Two patients developed ACG signs and symptoms after receiving aerosolized atropine for chronic obstructive pulmonary disease (COPD).

Findings:

  • Aerosolized anticholinergic agents, like atropine, may precipitate ACG in susceptible individuals.
  • Iris illumination can aid in identifying shallow anterior chambers, a risk factor for ACG.

Implications:

  • Screening for ACG risk factors, such as shallow anterior chambers and prior ACG symptoms, is crucial before initiating inhaled anticholinergic therapy.

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  • Ophthalmologist consultation is recommended for patients with risk factors prior to anticholinergic inhalant treatment to prevent ACG onset.