[Primary nodular lymphosarcoma of the breast]

A case of primary breast lymphosarcoma with axillary lymph node involvement and a local relapse after radical mastectomy has been described. The patient was a 43-year-old woman. Histologically, the primary tumour showed nodular (follicular) growth of prolymphocytes (centrocytes) and lymphoblasts (centroblasts) whereas the lymph node involved and relapsed tumour were characterized by diffuse proliferation of lymphoblasts (centroblasts). Immunocytochemistry revealed B-lymphocytic nature of the tumour cells. There were some difficulties in histological interpretation of this tumour due to both artificial structures and so-called lymphoepithelial lesions--remnants of ductal and lobular structures in the tumour tissue. The follicular type of growth of the primary breast lymphosarcoma is not in concordance with the current concept of histogenesis of the mucosa-associated lymphoid tissue lymphomas.