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Updated: Jul 2, 2026
07:25
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Sjögren's syndrome associated with multiple myeloma
I Tazi1, M Rachid, S Benchekroun
1Department of Haematology and Paediatric Oncology, Hospital 20 Août 1953, 20100 Casablanca, Morocco. tazi_illias@hotmail.com
Singapore Medical Journal
|August 30, 2008
Summary
Sjögren syndrome (SS) rarely presents as the initial symptom of multiple myeloma (MM). Treating the multiple myeloma led to the remission of Sjögren syndrome symptoms in this case.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Sjögren syndrome (SS) is a chronic autoimmune disorder primarily affecting exocrine glands.
- Multiple myeloma (MM) is a cancer of plasma cells, a type of white blood cell.
Observation:
- A 63-year-old woman presented with symptoms suggestive of Sjögren syndrome.
- Further investigation revealed IgA lambda multiple myeloma with diffuse lytic bone lesions.
- The patient experienced persistent thoracic pain, indicative of advanced disease.
Findings:
- The patient received VAD chemotherapy and bisphosphonate therapy for multiple myeloma.
- Following anti-myeloma treatment, the multiple myeloma regressed.
- Remarkably, Sjögren syndrome symptoms also resolved after MM treatment.
Implications:
- This case highlights the unusual presentation of multiple myeloma as Sjögren syndrome.
- The findings suggest a potential shared aetiopathogenic pathway between SS and MM.
- Effective MM treatment may lead to remission of associated SS symptoms.
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