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Published on: May 30, 2011
CT perfusion quantification of small-vessel ischemic severity
T J Huynh1, B Murphy, J A Pettersen
1Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
AJNR. American Journal of Neuroradiology
|September 5, 2008
Summary
Cerebral blood flow (CBF) is linked to white matter disease severity. CT perfusion (CTP) shows subcortical CBF is independently associated with white matter disease, even after accounting for age.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- White matter disease is associated with cerebral blood flow (CBF) abnormalities.
- A potential gradation of CBF changes exists with increasing white matter disease severity.
- Blood-brain barrier dysfunction, aging, and white matter disease are suggested to be interconnected.
Purpose of the Study:
- To quantify and correlate white matter disease severity with CT perfusion (CTP)-derived CBF.
- To investigate if permeability surface abnormalities increase with white matter disease severity.
Main Methods:
- Retrospective review of 35 patients with transient ischemic attack symptoms who underwent CTP and MR imaging.
- Two neurologists assessed white matter severity using age-related white matter change (ARWMC) scores.
- CBF, cerebral blood volume (CBV), mean transit time (MTT), and permeability surface product maps were calculated; associations with white matter severity were analyzed.
Main Results:
- Age was associated with moderate-to-severe white matter disease (P = .02).
- ARWMC scores correlated with subcortical (r = -0.50, P < .001) and average CBF (r = -0.55, P < .001).
- White matter severity was significantly associated with subcortical CBF (P = .03) after controlling for age.
Conclusions:
- CTP-derived subcortical white matter CBF is independently associated with white matter disease severity.
- No permeability surface abnormalities were detected in relation to white matter disease severity.
