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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Apoptosis signaling pathways

Richard M Siegel1, Michael J Lenardo

  • 1National Institute of Allergy & Infectious Diseases, Bethesda, Maryland, USA.

Current Protocols in Cytometry
|September 5, 2008
PubMed

Insights

Cell death, or apoptosis, involves complex molecular signaling pathways. This commentary explores active and passive apoptosis, crucial for understanding cell balance and disease.

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • Apoptosis is a regulated process of programmed cell death.
  • Molecular signals control pathways promoting cell survival or death.
  • These pathways interact with cell proliferation signals to maintain homeostasis.

Purpose of the Study:

  • To discuss the molecular signals governing apoptosis.
  • To describe two major apoptosis pathways: antigen-induced and lymphokine-withdrawal.
  • To provide background for flow cytometry analysis of apoptosis.

Main Methods:

  • Literature review and commentary on existing research.
  • Discussion of molecular signaling in apoptosis.
  • Conceptual overview of active and passive apoptosis.

Main Results:

  • Identification of crosstalk between apoptosis and proliferation pathways.
  • Characterization of antigen-induced (active) apoptosis.
  • Characterization of lymphokine-withdrawal (passive) apoptosis.

Conclusions:

  • Apoptosis is a critical, active process regulated by intricate molecular pathways.
  • Understanding these pathways is essential for maintaining cellular balance.
  • This commentary sets the stage for experimental analysis of apoptosis using flow cytometry.

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