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Updated: Jul 2, 2026

Optimization and Comparative Analysis of Plant Organellar DNA Enrichment Methods Suitable for Next-generation Sequencing
Published on: July 28, 2017
Nested genes and increasing organizational complexity of metazoan genomes
Raquel Assis1, Alexey S Kondrashov, Eugene V Koonin
1Center for Computational Medicine and Biology and the Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.
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