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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Synthesis of 3'- and 6'-functionalized locked nucleic acid (LNA) analogues
Pawan K Sharma1, Gerald Enderlin, Surender Kumar
1Department of Chemistry, Kurukshetra University, Kurukshetra-136 119, India. talk2pawan@gmail.com
Abstract:
Two locked nucleic acid (LNA) analogues, i.e. a 3'-C-hydroxymethyl derivative and a 6'(R)-hydroxymethyl derivative of the LNA thymidine monomer, have been synthesized efficiently using convergent strategies. The hydroxymethyl group at the 3'-position or the 6'-position provides a versatile starting point for various modifications of LNA.
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