Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA
Takumi Ishizuka1, Makoto Komiyama
1Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan.
Nucleic Acids Symposium Series (2004)
|September 9, 2008
Abstract:
We show that, in the presence of single-strand binding protein (SSB), one strand of peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in sequence-specific manner, as shown in Figure 1. In the absence of SSB, this kind of strand invasion never occurs. This significant enhancement of invasion can be applied to in vivo applications.
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