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Updated: Jul 1, 2026
15:22
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis and biochemical studies of tetraphosphate 5' mRNA cap analogs bearing bisphosphonate modification
Anna Rydzik1, Joanna Zuberek, Joanna Kowalska
1Division of Biophysics, Institute of Experimental Physics, University of Warsaw, 02-089 Warsaw, Poland.
Nucleic Acids Symposium Series (2004)
|September 9, 2008
Abstract:
Dinucleotide cap analogs containing tetraphosphate bridge modified by replacing one of the bridging oxygen atoms with methylene group were synthesized. The analogs have been examined for their stability towards enzymatic hydrolysis by human DcpS and binding affinity for eIF4E. Their inhibitory properties in rabbit reticulocyte lysate (RRL) translational system were studied.
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