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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Foldamers derived from nucleoside beta-amino acids: a new twist on the DNA helix
Richard Cosstick1, Richard Threlfall, Julie Fisher
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK. rcosstic@liv.ac.uk
Abstract:
Peptides derived from a thymidine beta-amino acid have been prepared by solid-phase synthesis and their conformation investigated by NMR. Interestingly, NMR and modelling studies indicate that the tetramer and octamer form an unusual 8-helical conformation. Studies are currently underway to investigate the synthesis of peptides derived from the other deoxyribonucleosides with the intention of examining the association between helices capable of nucleobase-pairing.
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