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Updated: Jul 1, 2026
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Total synthesis of a xylo-Puromycin analog
Benoît Y Michel1, Kollappillil S Krishnakumar, Peter Strazewski
1Laboratoire de Synthèse de Biomolécules, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (UMR 5246), Université Claude Bernard Lyon 1, 69622, Villeurbanne, France. benoit.michel@yahoo.fr
Abstract:
N(6)-bis-demethylated xylo-Puromycin analog 2 was synthesized in 56% over 6 steps from adenosine 3, involving a Mattocks bromo acetylation, a regio- and stereo-selective ribo-epoxide ring opening with sodium azide and an efficient Staudinger-Vilarrasa coupling reaction for which the conditions have been optimized.
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