Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SmartTrap: automated precision experiments with optical tweezers.

Nature methods·2026

Same author

Increased brightness of fluorescent uridine, qU, inside single- and double-stranded RNA.

Scientific reports·2026

Same author

Comments from the leaving Editor-in-Chief.

QRB discovery·2026

Same author

Expanding fluorescent base analogue labelling of long RNA by in vitro transcription.

The Journal of biological chemistry·2025

Same author

Monitoring nucleoside metabolism in living cells with a nucleobase analogue <i>via</i> fluorescence lifetime imaging.

Chemical communications (Cambridge, England)·2025

Same author

Adverse drug reactions following SARS-CoV-2 vaccination of 3805 healthcare workers cause substantial sick-leave and are correlated to vaccine regimen, age, sex and serological response.

Vaccine·2025

Same journal

A novel convenient method for high bacteriophage titer assay.

Nucleic acids symposium series (2004)·2009

Same journal

Expression behavior of high-pressure-compacted plasmid DNA in mammalian cell.

Nucleic acids symposium series (2004)·2009

Same journal

Role of exposed aromatic residues in substrate-binding of CBM family 5 chitin-binding domain of alkaline chitinase.

Nucleic acids symposium series (2004)·2009

Same journal

Incipient complex formation between AP endonucleases and DNA containing AP site: a vital role of the tryptophan residue.

Nucleic acids symposium series (2004)·2009

Same journal

Physiological role of RsgA in ribosome biosynthesis.

Nucleic acids symposium series (2004)·2009

Same journal

Trans-translation by tmRNA and SmpB.

Nucleic acids symposium series (2004)·2009

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Addressable molecular node assembly--high information density DNA nanostructures.

Erik Lundberg¹, John Tumpane, Ravindra Kumar

¹Department of Chemical & Biological Engineering/Physical Chemistry, Chalmers University of Technology, Kemivägen 10, SE-412 96, Gothenburg, Sweden. erik.p.lundberg@chalmers.se

Nucleic Acids Symposium Series (2004)

|September 9, 2008

Summary

This summary is machine-generated.

Researchers created a novel DNA nanostructure using three-way oligonucleotides. This smallest possible unit cell, a 3.4 nm hexagon, enables the construction of addressable two-dimensional DNA grids for nanotechnology applications.

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jul 1, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Area of Science:

* Nanotechnology
* Molecular Biology
* Materials Science

Background:

* DNA's intrinsic self-assembly capabilities are highly valuable for nanoscale engineering.
* Existing DNA nanostructures often face limitations in precise addressability and unit cell size.
* The development of novel oligonucleotide structures is crucial for advancing DNA nanotechnology.

Purpose of the Study:

* To engineer a fully addressable DNA nanostructure with an exceptionally small unit cell.
* To demonstrate the construction of a non-repetitive two-dimensional grid using novel DNA components.
* To leverage unique three-way oligonucleotides for precise spatial control in DNA self-assembly.

Main Methods:

* Design and synthesis of novel three-way oligonucleotides with unique addressable DNA sequences on each strand.
* Assembly of these oligonucleotides into a hexagonal unit cell with a 3.4 nm side-length.
* Characterization of the self-assembled nanostructure to confirm its addressability and grid formation.

Main Results:

* Successful creation of a DNA nanostructure featuring the smallest reported unit cell, a 3.4 nm hexagon.
* Demonstration of a fully addressable nanostructure, allowing for specific targeting and manipulation.
* Construction of a non-repetitive two-dimensional grid, showcasing precise spatial arrangement.

Conclusions:

* The novel three-way oligonucleotides facilitate the creation of highly precise and addressable DNA nanostructures.
* This work establishes a new benchmark for small unit cell sizes in DNA nanotechnology.
* The developed platform holds significant potential for advanced applications in molecular computing, drug delivery, and nanoscale fabrication.