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Neoplasia and paracoccidioidomycosis
M A Shikanai-Yasuda1, Y M T Conceição, A Kono
1Infectious and Parasitic Disease Dept., Laboratório de Investigação Médica em Imunologia do, Hospital das Clínica, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil. dmip.shikanai@hcnet.usp.br
Mycopathologia
|September 10, 2008
Summary
Cancer risk in paracoccidioidomycosis patients varies, with carcinoma being more common than hematological malignancies. Early diagnosis of both conditions is crucial for effective treatment and improved outcomes.
Area of Science:
- Mycology
- Oncology
- Infectious Diseases
Background:
- Published data on cancer and paracoccidioidomycosis (PMC) are limited to case reports and hospital cohorts.
- Neoplasia frequency in PMC patients ranges from 0.16% to 14.1%, with a mean of 3.96%.
Purpose of the Study:
- To analyze the association between cancer and paracoccidioidomycosis.
- To review existing literature on neoplasia incidence in PMC patients.
Main Methods:
- Review of published studies, including case reports and retrospective controlled studies.
- Analysis of biopsy and necropsy samples from PMC patients and control groups.
- Examination of autopsy data to determine cancer frequency in PMC patients.
Main Results:
- Carcinoma was more frequent than hematological malignancies in PMC patients.
- Cancer often occurred at sites affected by PMC, typically after PMC diagnosis.
- Lymphoma was linked to poorly organized, fungus-rich granulomas.
- Mortality was associated with cancer progression, secondary infections, and was worse in specific cancer types or chemotherapy patients.
Conclusions:
- The co-occurrence of cancer and PMC requires careful diagnosis, as clinical and histopathological findings can be similar.
- Accurate diagnosis of both PMC and neoplasia is essential for timely and safe intervention.
- Understanding this association can guide clinical management and improve patient outcomes.
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