[Correlation between syndrome factor combination and cardiac function as well as blood-lipid in coronary heart
Jie Wang1, Qing-Yong He, Zhan Shi
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Insights
Traditional Chinese Medicine (TCM) syndrome factor combinations in coronary heart disease (CHD) correlate with cardiac function and blood lipids. Specific TCM patterns like yang deficiency and blood stasis impact ejection fraction, while others affect lipid levels.
Area of Science:
- Integrative Medicine
- Cardiology
- Traditional Chinese Medicine
Context:
- Coronary heart disease (CHD) is a leading cause of mortality worldwide.
- Understanding the etiological patterns within Traditional Chinese Medicine (TCM) offers insights into disease mechanisms.
- TCM syndrome differentiation provides a framework for analyzing complex disease presentations.
Purpose:
- To investigate the distribution and correlation of Traditional Chinese Medicine (TCM) syndrome factor combinations in patients with coronary heart disease (CHD).
- To examine the relationship between specific TCM syndrome factor combinations and objective measures of cardiac function and blood lipid profiles in CHD patients.
Summary:
- A study of 300 CHD patients identified key TCM syndrome factor combinations: blood stasis due to qi deficiency, qi and yin deficiency, intermingled phlegm and blood stasis, and yang deficiency and blood stasis.
- Yang deficiency and blood stasis were associated with decreased ejection fraction.
- Intermingled phlegm and blood stasis correlated with elevated triglyceride and low-density lipoprotein cholesterol, while qi and yin deficiency was linked to increased triglyceride levels.
Impact:
- Findings support targeted TCM herbal medicine strategies for CHD, focusing on supplementing qi, activating blood circulation, nourishing yin, resolving phlegm, and activating yang.
- Treatment recommendations are tailored: activating yang and blood circulation for low cardiac function, and resolving phlegm, activating blood, and replenishing qi/yin for blood-lipid disturbances.
- This research bridges TCM diagnostics with Western medical parameters, potentially improving personalized treatment approaches for coronary heart disease.
Objective:
To discuss the distribution laws of traditional Chinese medicine (TCM) syndrome factor and their combination in coronary heart disease (CHD), and to study the correlation between the TCM syndrome factor combination and cardiac function as well as blood-lipid.
Methods:
The parameters of the cardiac function of 300 patients with a final diagnosis of CHD by coronary angiography were measured by echocardiography, and the levels of blood lipids in the CHD patients were detected. An analysis of the correlation was done between the TCM syndrome factor combination and cardiac function as well as blood-lipid in CHD.
Results:
The TCM syndrome factor combinations of CHD were blood stasis due to qi deficiency, qi and yin deficiency, intermingled phlegm and blood stasis, and yang deficiency and blood stasis. The ejection fraction of CHD patients with yang deficiency and blood stasis was markedly decreased. The levels of triglyceride and low-density lipoprotein cholesterol in CHD patients with intermingled phlegm and blood stasis were markedly increased, and the level of triglyceride in CHD patients with qi and yin deficiency was markedly increased too.
Conclusion:
The treatment of CHD should aim directly at the symptoms and causes. It is also proved that some compound traditional Chinese herbal medicines for supplementing qi and activating blood circulation, nourishing yin and resolving phlegm, and activating yang should be used in treatment of CHD. In cases of CHD with low cardiac function, particular emphasis should be laid on activating yang and blood circulation, while in cases of CHD with blood-lipid disturbance, particular emphasis should be laid on resolving phlegm and activating blood circulation, replenishing qi and nourishing yin.
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