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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Inflammation01:38

Inflammation

Overview
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

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Related Experiment Video

Updated: Jul 1, 2026

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

The atherosclerotic plaque.

J A Mundo-Sagardía1, Y Figueroa, P I Altieri

  • 1Department of Medicine, University of Puerto Rico, Medical Sciences Campus and Cardiovascular Center of Puerto Rico.

Puerto Rico Health Sciences Journal
|September 12, 2008
PubMed
Summary
This summary is machine-generated.

Atherosclerotic plaques cause heart disease and stroke. Understanding plaque instability and rupture is key to developing treatments for this common condition.

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Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
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Related Experiment Videos

Last Updated: Jul 1, 2026

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
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Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Area of Science:

  • Cardiovascular Medicine
  • Pathophysiology

Background:

  • Atherosclerosis is a primary cause of ischemic heart disease and cerebrovascular disorders.
  • It is the leading cause of mortality in Western countries.
  • Atherosclerotic plaques are central to the condition's development.

Purpose of the Study:

  • To discuss the pathophysiology of atherosclerotic plaques.
  • To identify factors contributing to plaque instability.
  • To review current medical interventions for managing plaque vulnerability.

Main Methods:

  • Review of existing literature on atherosclerosis pathophysiology.
  • Analysis of cellular and biochemical processes within atherosclerotic lesions.
  • Examination of current therapeutic strategies.

Main Results:

  • Atherosclerotic plaque structure involves complex biochemical and cellular interactions.
  • These interactions influence plaque vulnerability to rupture.
  • Plaque rupture can precipitate acute ischemic events.

Conclusions:

  • Understanding plaque pathophysiology is crucial for preventing ischemic events.
  • Targeting plaque instability offers a therapeutic avenue.
  • Current medical tools aim to counteract plaque-related risks.