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Updated: Jul 1, 2026

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

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Published on: July 11, 2025

Fetal asphyxia leads to a decrease in dorsal raphe serotonergic neurons.

Eveline Strackx¹, Daniël L A van den Hove, Hellen P Steinbusch

¹School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Developmental Neuroscience

|September 12, 2008

Summary

This summary is machine-generated.

Fetal asphyxia in rats leads to increased anxiety and reduced serotonin neuron density in adulthood. These developmental insults may predispose individuals to lifelong anxiety and brain changes.

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The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

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Published on: August 5, 2017

Area of Science:

Neuroscience
Developmental Biology
Behavioral Science

Background:

Fetal asphyxia (FA) is a critical event during birth that can impact brain development.
Serotonergic (5-hydroxytryptamine/serotonin, 5-HT) neurons in the dorsal raphe nucleus (DRN) play a crucial role in mood regulation.
Age-related changes in neuronal populations are common, but the impact of early-life insults on these changes is less understood.

Purpose of the Study:

To investigate the long-term effects of fetal asphyxia on anxiety behaviors.
To examine the impact of FA on the number, density, and volume of serotonergic neurons in the DRN.
To determine if FA exacerbates age-related changes in the serotonergic system.

Main Methods:

Fetal asphyxia was induced in rats at embryonic day 17.
Anxiety-related behaviors were assessed using the open field test.
Design-based stereology was employed to quantify 5-HT neurons in the DRN at 6 and 19 months of age.

Main Results:

Rats exposed to FA exhibited increased anxiety behaviors at 19 months of age compared to controls.
No significant differences in DRN 5-HT neuron numbers were observed at 6 months.
At 19 months, FA rats showed significantly reduced 5-HT neuron density and volume in the DRN.
An age-related decline in 5-HT neuron number, density, and volume was observed within the FA group.

Conclusions:

Fetal asphyxia is associated with heightened anxiety and alterations in the serotonergic system in aged rats.
These findings suggest that early-life asphyxia may predispose individuals to serotonergic dysfunction and anxiety disorders later in life.
Developmental insults during critical periods can have lasting consequences on brain development and behavior.