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Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

Sylvia E J Fischer1, Maurice D Butler, Qi Pan

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Nature
|September 12, 2008
PubMed
Summary

Researchers identified mutations in the eri-6 and eri-7 genes in Caenorhabditis elegans, revealing a novel RNAi pathway regulator. This helicase protein controls both exogenous and endogenous RNA interference pathways.

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