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Updated: Jul 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Peptoid architectures: elaboration, actuation, and application.

Barney Yoo¹, Kent Kirshenbaum

¹Department of Chemistry, New York University, 100 Washington Square E., Room 1001, New York, NY 10003, USA.

Current Opinion in Chemical Biology

|September 13, 2008

Summary

This summary is machine-generated.

Peptoids, or N-substituted glycine oligomers, offer precise sequence control for creating diverse compound libraries. New methods now direct their backbone conformation, enabling the discovery of protein mimetics.

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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

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Area of Science:

Polymer Chemistry
Biomolecular Engineering
Medicinal Chemistry

Background:

Peptoids are peptidomimetics built from N-substituted glycine units.
Their synthesis allows for precise control over monomer sequence and library generation.
Understanding peptoid sequence-structure-function relationships is an emerging research area.

Purpose of the Study:

To explore new methods for controlling peptoid backbone conformation.
To enable the formation of specific secondary structures in peptoids.
To advance the design and assembly of protein mimetics using peptoids.

Main Methods:

Development of novel synthetic strategies for peptoid backbone conformation control.
Investigation of methods to induce secondary structures like helices, loops, and turns.
Utilizing peptoid libraries to identify bioactive compounds.

Main Results:

Demonstrated successful direction of peptoid backbone conformation.
Achieved formation of defined secondary structures (helices, loops, turns).
Identified potential for discovering new bioactive peptoids.

Conclusions:

New approaches effectively control peptoid secondary structures.
These advances facilitate the discovery of bioactive peptoids.
Peptoids can serve as modules for designing protein mimetics.