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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

HOX proteins and leukemia.

Kajal V Sitwala1, Monisha N Dandekar, Jay L Hess

  • 1Department of Pathology, The University of Michigan Medical School Ann Arbor, Michigan, USA.

International Journal of Clinical and Experimental Pathology
|September 13, 2008
PubMed
Summary
This summary is machine-generated.

Homeobox (HOX) and TALE proteins drive leukemia development and are dysregulated in human leukemias. Understanding their cooperative mechanisms is crucial for developing targeted therapies.

Keywords:
HOXleukemia

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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Developmental Biology

Background:

  • Homeobox (HOX) and three amino acid loop extension (TALE) proteins are critical regulators of cellular processes.
  • These proteins are known to cooperate in inducing transformation in mouse leukemia models.
  • Dysregulation of HOX and TALE proteins is implicated in various human leukemias, yet their precise roles remain unclear.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying the cooperative action of HOX and TALE proteins in leukemia.
  • To investigate the roles of specific HOX (Hoxa9) and TALE (Meis1) proteins in leukemogenesis.
  • To leverage recent advances in genome-wide technologies to understand transcription factor programs.

Main Methods:

  • Analysis of mouse leukemia models.
  • Investigation of human leukemia samples.
  • Application of genome-wide technologies for transcription factor analysis.

Main Results:

  • HOX and TALE proteins cooperate to induce transformation in leukemia models.
  • Specific HOX and TALE proteins, like Hoxa9 and Meis1, are key players in leukemia.
  • New data from genome-wide studies are emerging to explain their functions.

Conclusions:

  • The synergistic action of HOX and TALE proteins is fundamental to leukemogenesis.
  • Further research utilizing advanced genomic tools is essential to fully understand these transcription factors in normal development and cancer.