Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Outcomes of Cervical Pulpotomy Using ZOE in Immature Permanent Teeth: A Retrospective Cohort Study.

Australian endodontic journal : the journal of the Australian Society of Endodontology Inc·2026
Same author

Insights into the July 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Insights into the June 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

PERSISTENT ORAL INFECTIONS MAY INCREASE THE RISK OF INFECTIOUS COMPLICATIONS IN ORGAN TRANSPLANT RECIPIENTS.

The journal of evidence-based dental practice·2026
Same author

Insights Into the May 2026 Issue of the JOE.

Journal of endodontics·2026
Same author

Interpreting Research Findings in Endodontics: A Biostatistical Primer.

Journal of endodontics·2026
Same journal

CLINICAL PARAMETER-BASED EVALUATION OF RESTORATIVE TREATMENT DIFFICULTY IN ENDODONTICALLY TREATED TEETH.

Journal of endodontics·2026
Same journal

Clinical Outcome of Replanted Avulsed Anterior Teeth: A Retrospective Cohort Study.

Journal of endodontics·2026
Same journal

Mahidol study 3: Post-operative Effect and Adverse Events of Regenerative Endodontic Procedures in Immature Permanent Teeth.

Journal of endodontics·2026
Same journal

Non-Surgical Management of Horizontal Root Fracture with Necrotic Apical Segment and Coronal Cervical Abfraction Using Mineral Trioxide Aggregate: Case Report.

Journal of endodontics·2026
Same journal

Identification of pain-related biomarkers and the associated potential molecular regulation mechanism in pulpitis by bioinformatics method.

Journal of endodontics·2026
Same journal

AI Prognostic Models in Endodontics: Scoping Review and Clinical Gap Analysis for Retreatment vs Microsurgery Decision Support.

Journal of endodontics·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Prion Safety Laboratory Swipe Test
06:01

Prion Safety Laboratory Swipe Test

Published on: February 14, 2025

Prion disease: the implications for dentistry.

Amir Azarpazhooh1, Edward D Fillery

  • 1Department of Endodontics, University of Toronto, Toronto, Ontario, Canada. amir.azarpazhooh@dentistry.utoronto.ca

Journal of Endodontics
|September 17, 2008
PubMed
Summary
This summary is machine-generated.

Prions, the agents causing fatal neurodegenerative diseases called transmissible spongiform encephalopathies (TSEs), resist sterilization. While dental transmission risk is very low, dentists should screen patients for prion disease risk factors.

More Related Videos

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species
12:00

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material
09:50

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Related Experiment Videos

Last Updated: Jul 1, 2026

Prion Safety Laboratory Swipe Test
06:01

Prion Safety Laboratory Swipe Test

Published on: February 14, 2025

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species
12:00

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material
09:50

Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material

Published on: September 29, 2017

Area of Science:

  • Dentistry
  • Infectious Diseases
  • Neurology

Background:

  • Transmissible spongiform encephalopathies (TSEs) are fatal, incurable neurodegenerative diseases.
  • Prion proteins, the infectious agents, are highly resistant to standard sterilization methods.
  • Definitive diagnosis of TSEs is only possible post-mortem.

Purpose of the Study:

  • To inform dental professionals about prion characteristics.
  • To assess the risk of prion transmission in dental settings.
  • To outline infection control implications for dentistry.

Main Methods:

  • Comprehensive literature search of medical and dental databases (MEDLINE, EMBASE, CINAHL, Cochrane Library).
  • Targeted internet search conducted up to July 2007.
  • Review of existing research on prion diseases and dental procedures.

Main Results:

  • No confirmed cases of prion disease transmission linked to dental procedures have been reported.
  • A theoretical, albeit extremely low, risk of prion transmission via dental instruments exists.
  • Prion resistance to sterilization poses a challenge for decontamination.

Conclusions:

  • Dental professionals must obtain thorough patient medical and family histories, including prion disease risk.
  • Maintaining up-to-date knowledge on prion diseases and infection control is crucial.
  • Ongoing research into prion diagnosis, transmission, and inactivation is vital for dental safety.