Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retinal Structure in Pre-Clinical Age-Related Macular Degeneration.

Current eye research·2017

Same author

Is percutaneous medial hamstring myofascial lengthening as anatomically effective and safe as the open procedure?

Journal of children's orthopaedics·2017

Same author

Retinal pigment epithelial cell necroptosis in response to sodium iodate.

Cell death discovery·2016

Same author

OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy.

Eye (London, England)·2015

Same author

Earlier therapeutic effects associated with high dose (2.0 mg) Ranibizumab for treatment of vascularized pigment epithelial detachments in age-related macular degeneration.

Eye (London, England)·2014

Same author

High-dose ranibizumab therapy for vascularized pigment epithelial detachment.

Eye (London, England)·2012

Same journal

Current Experimental Methods for Restoration of the Tear Film.

Current eye research·2026

Same journal

Apolipoprotein C3 Promotes Retinal Angiogenesis via the MYC Pathway in Hypoxia.

Current eye research·2026

Same journal

Possible Causal Association Between Thyroid-Related Traits and Diabetic Retinopathy Risk: Evidence From 23 Medication-Taking Traits.

Current eye research·2026

Same journal

Linking Microstructure to Mechanics in ICG-Stained Lens Capsules: Insights from Nanoindentation to Electron Microscopy.

Current eye research·2026

Same journal

Corneal Sensitivity, Sub-Basal Corneal Nerve Plexus, and Tear Neuropeptides in Symptomatic Versus Asymptomatic Visual Display Terminal Users.

Current eye research·2026

Same journal

Selective Laser Trabeculoplasty Mitigates Dexamethasone-Induced Myofibroblast-Like Transformation and Dysfunction in Human Trabecular Meshwork Cells.

Current eye research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Retinal function in X-linked ocular albinism (OA1).

S Nusinowitz¹, D Sarraf

¹UCLA School of Medicine, Jules Stein Eye Institute, Los Angeles, CA 90095, USA. nusinowitz@jsei.ucla.edu

Current Eye Research

|September 18, 2008

Summary

This summary is machine-generated.

Retinal function in ocular albinism (OA1) appears normal across the lifespan, though central vision shows reduced macular function. Age-related changes may differ in OA1 patients compared to controls.

More Related Videos

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Methodology for Studying Interactions of Vitamin A Membrane Receptors and Opsin Protein with their Ligands in Generating the Retinylidene Protein

Methodology for Studying Interactions of Vitamin A Membrane Receptors and Opsin Protein with their Ligands in Generating the Retinylidene Protein

Published on: October 4, 2024

Related Experiment Videos

Last Updated: Jun 30, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Methodology for Studying Interactions of Vitamin A Membrane Receptors and Opsin Protein with their Ligands in Generating the Retinylidene Protein

Methodology for Studying Interactions of Vitamin A Membrane Receptors and Opsin Protein with their Ligands in Generating the Retinylidene Protein

Published on: October 4, 2024

Area of Science:

Ophthalmology
Genetics
Retinal Physiology

Background:

Ocular albinism (OA1) is a genetic disorder affecting vision.
Understanding retinal function across the lifespan in OA1 is crucial for patient care.

Purpose of the Study:

To characterize retinal function in individuals with X-linked ocular albinism (OA1) throughout their lives.
To compare retinal function in OA1 patients with normal controls.

Main Methods:

Evaluated 14 OA1 patients and 5 obligate carriers using electroretinograms (ERG, mERG) and electro-oculography (EOG).
Compared results to age-matched normal controls.

Main Results:

Full-field ERG responses showed no group differences between OA1 patients and controls.
Multi-focal ERG (mERG) revealed reduced macular function and a flatter response topography in OA1 patients.
Electro-oculography (EOG) Arden ratios were normal but uncorrelated with age in OA1 patients.

Conclusions:

Panretinal function in OA1 is generally within normal limits, aligning with previous findings.
Reduced macular function in OA1 is consistent with anatomical studies of underdeveloped macula.
Potential differences in age-related retinal changes in OA1 warrant further investigation.