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Related Concept Videos

Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the translocon complex.
Simple Trusses01:21

Simple Trusses

A truss is a structural framework consisting of slender members connected at joints, designed to support external loads while minimizing material usage and weight. Simple trusses are a type of planar truss where all members lie within a single two-dimensional plane.
The most basic planar truss is a simple truss with three members arranged in a triangular formation. This triangular truss is inherently stable and rigid due to its geometry, making it an ideal starting point for creating more...
Space Trusses01:25

Space Trusses

A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
The Supercomplexes in the Crista Membrane01:41

The Supercomplexes in the Crista Membrane

The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
ATP Synthase: Structure01:18

ATP Synthase: Structure

ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
Space Trusses: Problem Solving01:29

Space Trusses: Problem Solving

A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. Due to its adaptability and capacity to withstand complex loads, the space truss is widely used in various construction projects.
Consider a tripod consisting of a tetrahedral space truss with a ball-and-socket joint at C. Suppose the height and lengths of the horizontal and vertical...

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Related Experiment Video

Updated: Jun 30, 2026

Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
09:41

Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale

Published on: May 14, 2020

The TRAPP complex: insights into its architecture and function.

Michael Sacher1, Yeon-Gil Kim, Arnon Lavie

  • 1Department of Biology, Concordia University, Montreal, QC, Canada. msacher@alcor.concordia.ca

Traffic (Copenhagen, Denmark)
|September 20, 2008
PubMed
Summary
This summary is machine-generated.

The TRAPP complex is crucial for vesicle transport, mediating protein delivery within cells. Recent studies explore its structure, function, and role in disease, clarifying its importance in cellular processes.

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Analyzing and Building Nucleic Acid Structures with 3DNA
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09:41

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Vesicle-mediated transport is essential for protein localization and secretion in all cells.
  • Tethering factors, like the TRAPP complex, ensure specific vesicle-target membrane interactions.
  • The TRAPP complex, with TRAPP I and TRAPP II forms, plays roles in endoplasmic reticulum-to-Golgi and trans-Golgi transport.

Purpose of the Study:

  • To review recent advances in understanding the TRAPP complex in yeast and mammals.
  • To elucidate the structural and functional aspects of TRAPP.
  • To explore the role of TRAPP in disease and resolve existing discrepancies.

Main Methods:

  • Literature review of structural and functional studies.
  • Analysis of TRAPP complex roles in cellular transport pathways.
  • Investigation of TRAPP's involvement in disease pathogenesis.

Main Results:

  • TRAPP complex is evolutionarily conserved and vital for vesicle tethering.
  • TRAPP I and TRAPP II have distinct roles in different transport steps.
  • TRAPP function is linked to various cellular processes and diseases.

Conclusions:

  • TRAPP complex is a key regulator of vesicle transport specificity.
  • Further research is needed to fully understand TRAPP's mechanisms and disease implications.
  • Structural and functional insights are advancing our knowledge of this critical cellular machinery.