Eruptive acral lentigines--a new paraneoplastic sign?

Cutaneous signs may be the first indications of an internal disease. Any definitive sign of a neoplastic disease is of special importance since early diagnosis and early treatment may make a telling difference in improving prognosis. Presented is a 68-year-old patient with advanced stage melanoma that was associated with the appearance of multiple acral lentigines. The exact time-course of onset of the lentigines in relation to the formation of the melanoma could not be established. However, from the information we could take out of our patient, it is clear that the lentigines had appeared either shortly before or after the appearance of the melanoma. In conclusion we suggest that the present case represents a new paraneoplastic sign.