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Published on: September 26, 2019
[Atopic exzema in adulthood]
1Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Deutschland.
Summary
Adult atopic eczema (AE) affects 1-3% of adults, often persisting from childhood or appearing initially in adulthood. Stress is a key trigger, with current treatments focusing on symptom management rather than a cure.
Area of Science:
- Dermatology
- Immunology
- Genetics
Context:
- Atopic eczema (AE) affects 1-3% of adults, with persistence from childhood or new onset possible.
- Predictors for adult AE include family history, early onset, childhood severity, and co-occurring atopic disorders.
- Genetic factors are implicated, and stress is a significant trigger for AE.
Purpose:
- To review the epidemiology, risk factors, and current management strategies for adult atopic eczema.
- To highlight the challenges in treating severe adult AE and outline advanced therapeutic options.
Summary:
- Adult AE prevalence is 1-3%, influenced by genetic and environmental factors like stress.
- Treatment involves skin care, emollients, antiseptics, and antipruritics, with topical corticosteroids or calcineurin inhibitors for exacerbations.
- Severe cases unresponsive to topical treatments may require phototherapy or systemic immunosuppressive/immunomodulatory drugs.
Impact:
- Provides a comprehensive overview of adult atopic eczema for clinicians and researchers.
- Informs therapeutic decisions for managing persistent or severe adult AE.
- Underscores the need for further research into causal therapies for atopic eczema.
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