Related Experiment Video
Updated: Jun 30, 2026

Mouse Models of Periventricular Leukomalacia
Published on: May 18, 2010
A progressive neurologic disorder with multiple CNS lesions: a neuroimaging clinicopathologic correlation.
Sajeel Chowdhary1, Marc Chamberlain
1Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA.
Abstract:
A 51-year-old man with a diagnosis of myelodysplasia and non-Hodgkin's lymphoma underwent an unmatched allogenic bone marrow transplantation and was treated posttransplant with chronic immunosuppressive medication. Eight months following transplantation, he presented with progressive dysarthria, cognitive and visual decline. Evaluation included brain magnetic resonance (MR) imaging demonstrating multifocal areas of increased T2 and FLAIR (fluid attenuated inversion recovery) signals involving the left frontal, parietal, and occipital lobes. The MR lesions demonstrated diffuse increased signal on DWI (diffusion-weighted images) and normal to low signal on ADC (apparent diffusion coefficients). Contrast-enhanced T1 images were unremarkable. Lumbar puncture revealed a mild elevation in cerebrospinal fluid (CSF) protein. CSF PCR assay for viral DNA fragments were negative on two occasions. Serum serology for HIV was negative as well. A brain biopsy was subsequently performed. The clinical and neuroimaging differential diagnoses as well as neuropathologic correlation are presented.
Related Concept Videos
Multiple Sclerosis l: Introduction
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Parkinson's Disease: Overview
Parkinson Disease ll: Pathophysiology
Alzheimer Disease ll: Pathophysiology

