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Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
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[Progress in the research of stanniocalcin].
1Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|September 30, 2008
Summary
Stanniocalcin (STC) is a hormone regulating calcium and phosphate. It is also a novel marker for human cancer and plays roles in heart disease and embryo implantation.
Area of Science:
- Endocrinology
- Biochemistry
Context:
- Stanniocalcin (STC) is a glycoprotein hormone initially found in bony fish.
- It plays a crucial role in maintaining calcium and phosphate balance.
Purpose:
- To explore the diverse roles of Stanniocalcin (STC) in human physiology and disease.
- To highlight STC as a potential biomarker in various medical conditions.
Summary:
- Stanniocalcin (STC) is identified in humans and mammals as STC1 and STC2.
- The STC1 gene produces STC50 and big STC variants.
- Both STC1 and STC2 are expressed across numerous tissues.
Impact:
- STC is recognized as a novel marker for human cancers.
- It is implicated in the pathogenesis of heart disease.
- STC influences inflammatory cell migration, embryo implantation, and decidualization.
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