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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jun 29, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Brain imaging in pediatric obsessive-compulsive disorder.

Frank P MacMaster1, Joseph O'Neill, David R Rosenberg

  • 1Department of Psychiatry, Wayne State University, USA.

Journal of the American Academy of Child and Adolescent Psychiatry
|October 2, 2008
PubMed
Summary

Pediatric obsessive-compulsive disorder (OCD) research refines the frontal-striatal-thalamic model, implicating genetics and glutamate. This advances evidence-based treatments for childhood OCD.

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Related Experiment Videos

Last Updated: Jun 29, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Area of Science:

  • Neuroscience
  • Genetics
  • Child Psychiatry

Background:

  • Pediatric obsessive-compulsive disorder (OCD) is a debilitating condition.
  • Understanding its underlying mechanisms is crucial for effective treatment.

Purpose of the Study:

  • To review advancements in understanding pediatric OCD.
  • Focus on the frontal-striatal-thalamic model, neurobiology, genetics, and treatment implications.

Main Methods:

  • Comprehensive literature search using keywords: "obsessive-compulsive disorder," "pediatric," "genetics," and "imaging."

Main Results:

  • Neuroimaging supports the frontal-striatal-thalamic model in pediatric OCD.
  • Genetic and neurochemical studies highlight glutamate's role in OCD pathology.
  • Glutamate-modulating agents are being explored for OCD treatment.

Conclusions:

  • Research has refined the frontal-striatal-thalamic model for pediatric OCD pathogenesis.
  • Findings are influencing evidence-based treatment strategies.
  • Further research is needed for comprehensive models, accurate prognosis, and targeted therapies.