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Related Concept Videos

Bicarbonate-Carbonic Acid Buffer01:22

Bicarbonate-Carbonic Acid Buffer

The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids

In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
Roles of Electrolytes: Chloride and Bicarbonate01:29

Roles of Electrolytes: Chloride and Bicarbonate

Chloride ions contribute to the osmotic pressure gradient distinguishing the intracellular fluid (ICF) from the extracellular fluid (ECF). They counterbalance positively charged ions in the ECF and ensure its electrochemical stability. The renal system's process of chloride absorption and release generally mirrors that of sodium ions.
Conditions such as hypochloremia can arise from insufficient chloride reabsorption by the kidneys, often compounded by extended bouts of diarrhea, vomiting, or...
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...

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Related Experiment Video

Updated: Jun 29, 2026

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
08:07

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic

Published on: October 4, 2024

Sodium bicarbonate: basically useless therapy.

Judy L Aschner1, Ronald L Poland

  • 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-9544, USA. judy.aschner@vanderbilt.edu

Pediatrics
|October 3, 2008
PubMed
Summary

Sodium bicarbonate is often given to neonates without strong evidence of benefit. This review finds that this common practice may actually harm infants, especially during cardiopulmonary arrest or metabolic acidosis in the NICU.

Area of Science:

  • Neonatology
  • Pediatric Critical Care
  • Biochemistry

Background:

  • Sodium bicarbonate is a common treatment in neonatal care.
  • Its use is widespread despite limited supporting evidence.
  • Concerns exist regarding potential adverse effects.

Purpose of the Study:

  • To review the historical use of sodium bicarbonate in neonates.
  • To examine the evidence refuting its efficacy in cardiopulmonary arrest and metabolic acidosis.
  • To critically evaluate current clinical practices in neonatal intensive care units (NICU).

Main Methods:

  • Literature review of historical and current studies.
  • Analysis of experimental evidence regarding sodium bicarbonate's effects.
  • Examination of clinical outcomes in neonates receiving the therapy.

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Published on: July 31, 2019

Related Experiment Videos

Last Updated: Jun 29, 2026

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic
08:07

Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic

Published on: October 4, 2024

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

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Main Results:

  • Objective evidence supporting sodium bicarbonate's benefit in neonatal cardiopulmonary arrest or metabolic acidosis is lacking.
  • There is evidence suggesting that sodium bicarbonate administration can be detrimental to neonates.
  • Current clinical practices are not well-supported by scientific data.

Conclusions:

  • The routine administration of sodium bicarbonate in neonates lacks robust evidence of efficacy.
  • This practice may pose risks and potentially worsen outcomes.
  • Neonatal resuscitation and metabolic acidosis treatment protocols should be re-evaluated based on available evidence.