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Updated: Jun 29, 2026
08:17
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
[Fisher syndrome with optic neuropathy]
Noriko Koga1, Hiroshi Ishikawa, Yuu Itou
1Division of Ophthalmology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry. 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan. norikoga@dent-meikai.ac.jp
Nippon Ganka Gakkai Zasshi
|October 7, 2008
Summary
Fisher syndrome, a rare neurological disorder, can affect vision and eye movements. This case highlights Fisher syndrome complicating optic neuropathy, with symptoms improving after treatment.
Area of Science:
- Neurology
- Ophthalmology
- Immunology
Background:
- Fisher syndrome is a rare variant of Guillain-Barré syndrome.
- Optic neuropathy is an uncommon complication of Fisher syndrome.
Observation:
- A 78-year-old male presented with dizziness, blurred vision, absent reflexes, and progressive external ophthalmoplegia.
- Ophthalmic examination revealed severely reduced visual acuity and absent pupillary reflexes.
- Serum analysis detected anti-GQ1b and anti-GT1a antibodies.
Findings:
- Intravenous immunoglobulin therapy resolved neurological deficits, including optic neuropathy and ophthalmoplegia.
- Persistent pupillary dilatation with light-near dissociation indicated peripheral nervous system involvement.
Implications:
- This case underscores the potential for Fisher syndrome to involve optic neuropathy.
- Early diagnosis and treatment are crucial for managing this rare neurological presentation.
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