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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...

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Updated: Jun 29, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53 family in development.

Nadia Danilova1, Kathleen M Sakamoto, Shuo Lin

  • 1Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, 615 Charles E. Young Drive South, BSRB 454, Los Angeles, CA 90095-1606, USA. ndanilova@ucla.edu

Mechanisms of Development
|October 7, 2008
PubMed
Summary
This summary is machine-generated.

The p53 protein family regulates cellular responses to stress and suppresses tumors by preserving genome integrity. Emerging research reveals their broader role in controlling cell proliferation, differentiation, and death, with imbalances linked to human developmental abnormalities.

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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
10:55

Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The p53 protein family acts as a central processor integrating cellular signals.
  • Its primary known function is in stress response and tumor suppression, maintaining genomic integrity.
  • Recent findings suggest a more extensive role in regulating cell fate decisions.

Purpose of the Study:

  • To elucidate the multifaceted roles of the p53 protein family.
  • To explore their involvement in cell proliferation, differentiation, and apoptosis.
  • To investigate the link between p53 family imbalance and human congenital developmental abnormalities.

Main Methods:

  • Literature review of recent studies on p53 family network.
  • Analysis of data implicating p53 in broader cellular processes.
  • Correlation analysis of p53 family function and developmental disorders.

Main Results:

  • The p53 family coordinates cellular fate choices: proliferation, arrest, differentiation, senescence, and apoptosis.
  • Members with opposing activities regulate these processes.
  • Dysregulation of the p53 network is associated with human congenital abnormalities.

Conclusions:

  • The p53 protein family plays a critical role beyond tumor suppression, influencing fundamental cellular processes.
  • Understanding the p53 network's coordination is key to comprehending normal development and disease.
  • Imbalances in the p53 family network represent a significant factor in human congenital developmental abnormalities.