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Published on: October 2, 2020
Correlation between physical functioning and sleep disturbances in hemodialysis patients
Ramsey Sabbagh1, Sameena Iqbal, Murray Vasilevsky
1Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada. ramsey.sabbagh@mail.mcgill.ca
Hemodialysis International. International Symposium on Home Hemodialysis
|December 5, 2008
Summary
Physical functioning impacts sleep quality in chronic hemodialysis patients. Lower physical activity scores correlate with increased sleep disturbance, even when accounting for inflammation and dialysis adequacy.
Area of Science:
- Nephrology
- Sleep Medicine
- Cardiovascular Health
Background:
- Chronic hemodialysis (HD) patients often experience sleep disturbances.
- Inflammatory status and physical functioning are potential contributing factors to poor sleep in this population.
Purpose of the Study:
- To investigate the relationship between physical functioning, inflammatory status, and sleep disturbance in maintenance hemodialysis patients.
- To identify predictors of poor sleep quality in this cohort.
Main Methods:
- Forty-six maintenance HD patients were assessed using the Human Activity Profile (HAP) and RAND 36-item survey for physical functioning.
- Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI).
- Inflammatory status was determined by C-reactive protein (CRP) levels, with analyses controlling for dialysis adequacy, inflammation, and hemoglobin.
Main Results:
- Seventy-six percent of patients reported poor sleep (PSQI score ≥ 5).
- Sixty-five percent had elevated CRP levels (>5 mg/L).
- Univariate analysis showed significant associations between poor sleep, high CRP, and lower adjusted activity scores (AAS) on the HAP. Multivariate analysis confirmed AAS as a significant predictor, with each HAP AAS increase reducing odds of poor sleep by 6%.
Conclusions:
- Poor physical functioning, as measured by the HAP, is significantly associated with sleep disturbance in chronic HD patients.
- This association persists after controlling for inflammatory status and dialysis adequacy.
- Interventions aimed at improving physical functioning may help mitigate sleep disturbances in hemodialysis patients.
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