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DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions
Jingkai Yu1, Svetlana Pacifico, Guozhen Liu
1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 East Canfield Ave., Detroit, MI 48201, USA. jingkai@wayne.edu
BMC Genomics
|October 9, 2008
Summary
DroID is a comprehensive database for Drosophila gene and protein interactions, offering integrated expression data and confidence scores for biological discovery. It provides easy access to interaction data for researchers studying this model organism.
Area of Science:
- Genomics and Bioinformatics
- Molecular Biology
- Systems Biology
Background:
- Understanding gene and protein interactions is crucial for deciphering biological systems.
- High-throughput technologies generate vast amounts of interaction data, necessitating efficient access.
- Existing multi-organism databases struggle to maintain comprehensive data for individual model organisms like Drosophila melanogaster.
Purpose of the Study:
- To develop a comprehensive and specialized database for Drosophila gene and protein interactions.
- To integrate diverse interaction data types, gene expression, and gene information.
- To provide robust search, filtering, and analysis tools for Drosophila researchers.
Main Methods:
- Developed DroID (Drosophila Interactions Database), a specialized resource for Drosophila.
- Integrated published physical, genetic, and computationally predicted interactions, including interologs.
- Incorporated gene expression and correlation data, with an updatable confidence scoring system for physical interactions.
- Enabled searching and filtering via gene attributes from Flybase and interaction data.
Main Results:
- DroID offers the most comprehensive collection of Drosophila interactions.
- Interactions are annotated with experimental data, source information, gene expression, and confidence scores.
- The database facilitates focused studies on co-expressed gene networks.
Conclusions:
- DroID is the premier Drosophila interactions database, enhancing downstream analysis.
- Freely available data can be accessed and downloaded via web, Java applet, and Cytoscape plug-in.
- The resource supports biological systems research by providing integrated and curated interaction data.
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