Enantioselective synthesis of indolizidine alkaloid trans-209D
1Unitat de Recerca en Síntesi Asimètrica (URSA-PCB), Institute for Research in Biomedicine, and Departament de Química Orgànica, Universitat de Barcelona, Parc Científic de Barcelona c/ Baldiri Reixac, 10, Barcelona 08028, Spain.
The Journal of Organic Chemistry
|October 10, 2008
Abstract:
(S)-N-Boc-baikiain, readily accessible from enantiomerically enriched 2,3-epoxy-5-hexen-1-ol 4 (prepared by Sharpless asymmetric epoxidation), was used as the starting material in the synthesis of indolizidine alkaloid trans-209D , which was obtained in 13 steps and 14% yield from 1 (5% from 4).
