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Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
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[Single-embryo transfer: Rennes' Hospital experience].

D Le Lannou1, M-C Laurent, J-F Griveau

  • 1Service de Médecine et Biologie de la Reproduction, CHU Hôpital-Sud, 35000 Rennes, France. dominique.lelannou@chu-rennes.fr

Gynecologie, Obstetrique & Fertilite
|October 14, 2008
PubMed
Summary
This summary is machine-generated.

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Single-embryo transfer (SET) in assisted reproduction reduces multiple pregnancies to 12% while maintaining a 39% cumulative pregnancy rate. This approach, combined with embryo cryopreservation, offers a safer path to conception.

Area of Science:

  • Reproductive Medicine
  • Embryology
  • Gynecology

Context:

  • Assisted Reproductive Technology (ART) Centre of Rennes' Hospital, France.
  • Study period: 2005-2006, involving 905 oocyte punctures.
  • High rates of pregnancy from both fresh and frozen embryo transfers were observed.

Purpose:

  • To evaluate the efficacy and safety of single-embryo transfer (SET) in reducing multiple pregnancies.
  • To assess the impact of SET on cumulative pregnancy rates when combined with embryo cryopreservation.
  • To analyze SET outcomes in patients under 38 with specific embryo quality.

Summary:

  • Single-embryo transfer (SET) was offered to 63% of eligible patients (293 cycles), resulting in a 21.5% pregnancy rate per fresh transfer.
  • Frozen embryo transfers following SET were performed in 708 cycles, achieving a 16.8% pregnancy rate.

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  • The overall cumulative pregnancy rate per oocyte puncture reached 39%, with a significant reduction in multiple pregnancies to 12%.

    • Impact:

    • Demonstrates that SET significantly lowers the risk of multiple births in assisted reproduction.
    • Highlights the effectiveness of combining SET with robust embryo cryopreservation protocols.
    • Confirms that this strategy maintains high cumulative pregnancy rates, improving patient outcomes.