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Updated: Jun 18, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
Effect of cibenzoline and atenolol administration on dynamic left ventricular obstruction due to sigmoid-shaped
Kazuyuki Ozaki1, Ikki Sakuma, Koko Mitsuma
1Department of Cardiology, Niigata City General Hospital, Niigata, Japan. k-ozaki@hosp.niigata.niigata.jp
Abstract:
Obstruction of the left ventricular outflow tract (LVOT) is usually complicated by hypertrophic cardiomyopathy or left ventricular hypertrophy. It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of the LVOT were observed. Their complaints were dyspnea on effort and exercise increased the left ventricular pressure gradient. In both cases, atenolol administration decreased rest pressure gradient. Moreover, additional cibenzoline administration decreased the pressure gradient caused by exercise. It is emphasized that dual therapy with cibenzoline and atenolol is effective in resolving the obstruction of the LVOT caused by SS.
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