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[Experimental study of per-rectal portal scintigraphy using 99mTc-EHIDA]
S Tamaki1, A Shinotsuka, H Takenaka
1Department of Radiology, Showa University School of Medicine.
Summary
Rectal administration of technetium-99m-labeled ethoxyisonitrile (99mTc-EHIDA) allows for effective portal system visualization. This noninvasive method shows promise for evaluating portal circulation in both animal models and potentially humans.
Area of Science:
- Nuclear Medicine
- Diagnostic Imaging
- Gastroenterology
Background:
- Hepatobiliary scintigraphy commonly uses 99mTc-EHIDA.
- Evaluating the portal system often requires invasive methods.
Purpose of the Study:
- To assess the utility of per-rectal 99mTc-EHIDA for portal scintigraphy.
- To compare rectal 99mTc-EHIDA with other radiotracers for portal circulation assessment.
Main Methods:
- Rabbits (normal and portal shunt models) received rectal 99mTc-EHIDA, 123I-IMP, and 99mTc-RBC.
- Liver and thorax images were acquired to calculate shunt indices.
- Results were correlated with direct 99mTc-MAA injection into the mesenteric vein.
Main Results:
- Per-rectal 99mTc-EHIDA demonstrated adequate absorption and optimal portal system visualization.
- 99mTc-EHIDA achieved the highest correlation (0.78) with direct shunt rate measurements.
- It outperformed 99mTc-RBC (0.64) and 123I-IMP (0.75).
Conclusions:
- Per-rectal 99mTc-EHIDA portal scintigraphy is a noninvasive, quantitative, inexpensive, and simple method.
- This technique is effective for evaluating the portal circulation system.
- The method shows potential for human application based on volunteer experiences.