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Patterns of duodenal osmolality in young pigs fed solid food
1Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
The American Journal of Physiology
|September 1, 1991
Summary
Duodenal osmolality increases after meals, potentially influencing meal size. However, drinking water significantly reduces this hyperosmolality, suggesting a regulatory role in food intake.
Area of Science:
- Gastroenterology
- Physiology
- Nutritional Science
Background:
- Duodenal hypertonicity is known to induce satiety.
- The variation in duodenal osmolality during eating and its effect on meal size remain unclear.
Purpose of the Study:
- To investigate the changes in duodenal osmolality during and after meals under different feeding conditions.
- To determine if duodenal osmolality variations influence meal size.
Main Methods:
- Duodenal fluid samples were collected from 10 young pigs using implanted catheters.
- Three feeding conditions were tested: meal with water, meal without water, and spontaneous eating and drinking.
- Duodenal osmolality was measured in mosmol/kgH2O.
Main Results:
- Duodenal osmolality peaked at 430 mosmol/kgH2O with a meal and water, returning to baseline in 2.2 hours.
- Without water, osmolality reached 418 mosmol/kgH2O and took 4.2 hours to normalize.
- Spontaneous meals showed a smaller osmolality increase (281 to 308 mosmol/kgH2O) due to water intake and smaller meal sizes.
Conclusions:
- Duodenal osmolality significantly increases after meals.
- Water consumption effectively moderates postprandial duodenal hyperosmolality.
- These findings suggest a role for duodenal osmolality in regulating food intake.