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Diagnosis of renal tumor by gamma-glutamyltranspeptidase (EC 2.3.2.2)
Urology
|January 1, 1976
Abstract:
A urinary enzyme pattern and kidney tissue pattern were investigated simultaneously in 117 urologic patients. In contrast to all other renal disorders only the sixteen malignant tumors of the kidney showed a significant drop of gamma-GT in tumor tissue and urine. So far urinary enzymology has been used only as screening test. Measurement of gamma-GT in urine, however, permits the diagnosis of kidney tumors.
Insights
This study reveals that a significant drop in gamma-glutamyl-transferase (GGT) in both kidney tumor tissue and urine can diagnose malignant kidney tumors. This enzyme pattern offers a new diagnostic method for renal cell carcinoma.
Area of Science:
- Urologic oncology
- Diagnostic enzymology
Background:
- Urinary enzyme patterns are used for screening renal disorders.
- Kidney tissue and urinary enzyme analysis can provide diagnostic insights.
Purpose of the Study:
- To investigate urinary and kidney tissue enzyme patterns in urologic patients.
- To determine if specific enzyme changes correlate with malignant kidney tumors.
Main Methods:
- Simultaneous analysis of urinary enzyme patterns and kidney tissue in 117 urologic patients.
- Focus on gamma-glutamyl-transferase (GGT) levels in tumor tissue and urine.
Main Results:
- A significant decrease in GGT was observed in tumor tissue and urine of patients with malignant kidney tumors.
- This GGT drop was specific to malignant renal tumors compared to other renal disorders.
Conclusions:
- Measurement of urinary GGT levels can aid in the diagnosis of kidney tumors.
- Urinary enzymology, specifically GGT measurement, offers a diagnostic tool beyond screening for renal malignancy.